Sex and aggression in mice controlled by cold-sensor in brain

Testosterone is blamed for sex drive and aggression, but it also appears to be critical for telling the brain “enough!” when it comes to those behaviors. A molecule called TRPM8 (pronounced trip-M-8) embedded in the surface of some cells seems to be responsible for sending these cues in response to testosterone. Without these cues, male mice become dangerously aggressive and have an insatiable appetite for sex. This research, by Eleonora Zakharian and colleagues at the University of Illinois College of Medicine, will be presented at the 63rd Biophysical Society Annual Meeting, to be held March 2—6, 2019 in Baltimore, Maryland.