It’s no secret that our genes are what makes us… us! But genes are often also the basis for debilitating diseases. One of the major clues to understanding any illness is seeing which genes are acting unusually during disease onset. But it’s not often clear if unusual gene activity is unique to the disease at hand, or is merely a more general symptom of an unhealthy body. Now, scientists at Cold Spring Harbor Laboratory (CSHL) have crafted a ranked list of usual suspects that could prove invaluable for researchers and clinicians.